Why is the reaction to vaccines against David-19 more pronounced in women?

Over the past year, we learned that gender changes can affect immune response. That's also true of vaccines. Women seem to respond more strongly to immunization and report the side effects more often.

According to a US Centres for Disease Control and Prevention report (CDC) on security data from the first 13.7 million doses of US-administration vaccines, 79.1% of side reactions related to vaccines are reported by women, although only 61.2% of vaccines have been injected to female patients.

Almost all rare reactions concern women, 4.5 cases in every 1 million administered doses, and all addressed immediately and without complications. According to Juliane Gee's Immunification Security physician, interviewed by the New York Times, women usually experience more reactions, in terms of vaccines, flu vaccines in anti-virgin vaccines, shytes, and rubella.

Almost all side reactions related to anti-David vaccines as well; one or two days of fever, fatigue, headache, pain in the place of vaccine, are light or moderate, quickly disappear and, above all, indicate the activism of the immune system and the fact that the vaccine is working. The important thing is to be informed and prepared to manage them.

But why are such reactions more pronounced in women?

This could be partly for hormonal reasons. Sexual hormones such as estrogen, progesterone, and testosterone can bind to the surface of immune cells and influence their behavior. Estrogen stimulates immune cells to produce more antibodies in response to flu vaccines.

The testosterone, however, has an immune action. Hormonal factors have repeatedly been questioned to explain the increase in the mortality of the CoViD-19 men.

Other reasons are perhaps genetic. Many genes that regulate immune factors are in the X chromosome, of which women have two in each cell. This may also explain why 80% of autoimmune diseases occur in the female gender.

But it can also depend on the dose of anti-David vaccines. The female physicist absorbs drugs differently than male, but historically, experimental preparations are tested mainly in men.

Although the problem has been partially solved in modern clinical trials, those of anti-convidian vaccines are not yet scheduled to test the effectiveness of the lowest doses of vaccine in the female body, in order to prevent excessive possible reactions.