English scientist: That's why kids get leukemia.

As part of London's Cancer Research Institute, Graves has been studying leukemia in children for three decades. This Friday he was rewarded for his medical work. For thirty years I've been curious about the reasons for the baby's leukemia disease. For the first time, we have the answer to that question. This means that we can start thinking about ways to prevent this disease”, says the scientist.

In the 1950 ' s, acute leukemia affecting more than two thousand children within the year of Great Britain was deadly. Today, 90 percent of the cases are healed, although treatment is poisonous and can bring lasting side effects. Scientists have found that the number of cases with the disease is increasing by 1 percent annually, broadcast the Express.

Acute lymphoblastic leukemia is caused by a series of biological processes. The first sign is a genetic mutation that appears in about 5 percent of children. This mutation is caused by an accident in the womb. It is not inherited but puts the child in danger of developing leukemia later in life”, says Greaves.

The full display of leukemia occurs when another biological process takes place, which includes the immune system. “immune system only works properly if facing an infection in the first year of life”, the professor says. Without this confrontation, the system remains unprepared and will not function properly.

This issue is becoming a growing problem. Parents are raising their children in homes where antiseptic materials, antibacterial soaps, and disinfectant floor cleaning are common. Moreover, children are less breast - fed and tend to have less association with other children. Both phenomena reduce children's contact with germs. This has its own positive side, but it also has side effects. The child's immune system is not being prepared over time because they are not being exposed to germs and infections.

When a baby that was not infected before is exposed to common infections, its immune system reacts abnormally. This causes an excessive reaction, which stimulates chronic inflammation”, Greaves says. During the development of inflammation, cytokins are released in the blood, which can stimulate the creation of a second mutation that causes leukemia in children with the first mutation, the Express broadcasts.

In other words, children with chronic second mutations have likely fallen into this state because of super clean and modern homes. From this perspective, the disease is not related at all to the power lines or the nuclear material reprocessing stations, as previously estimated, but is caused by a series of prenatal and environmental processes, Greaves stressed in “Nature Reviews Cancer” earlier this year.

This new view of the disease gives scientists an opportunity to intervene and stop the development of leukemia in the first place, says the scientist. “We don't know yet how to stop presenting the first mutation before birth, but we can think about blocking chronic inflammation that later appears”, he says.

To accomplish this, Greaves and his team have begun working on bacteria, viruses, and other microbes that live in human bowels. Unless they help us to digest the food, they tell us about the kind of germs we've faced in life. For example, people in developed countries usually have fewer bacteria in their intestines. This is because they have been exposed to a smaller number of microbes in early stages of life.

We need to find a way to rebuild these people. We also need to find out what are the most important types of microbes to prepare children's immune system”, Greaves says. To accomplish this, he is experimenting with mice to find out which germs stimulate the rodent's immune system. The goal is for such experiments to be done in people after two or three years.

Our point is to find six to ten species of germs that have the most ability to put the child's microbiom in fat. This germs cocktail would be served as a drink for young children”, the scientist adds. According to him, this drink would also affect the prevention of other diseases. Type 1 diabetes and allergies are believed to be linked to the lack of infant exposure to the immune system's roasting bacteria. Hence, it is believed that such a mixture of microbes would affect the decline in cases of people facing these problems.

I think the perspective is very attractive. I think we could use this to reduce the risk of leukemia and a certain number of diseases”, Greaves says. Blood cells are produced in bone marrow. Red cells, which carry oxygen through the body, white cells that fight infections, and blood platelets that stop the bleeding, are created when the body needs them. But when a person has leukemia, many white cells are released that prevent normal cells from growing in the bone marrow. As a result of this condition, the amount of red, white cells and blood platelets shrink, and health problems begin.

Among many species of leukemia, the two most frequent species in children and young people are acute lymphoblastic leukemia and acute meloide leukemia, writes the Guardian<18x1>.